Endocrine Abstracts

Introduction: Pituitary adenomas (PA) represent approximately 15% of all intracranial neoplasms, with a global incidence of 15,20 per million per year. The immunohistochemical analysis of PA is necessary for diagnosis and plays an important role in the modern classification system of pituitary tumors.Material and methods: Samples from 142 surgically resected PA were studied immunohistochemically using antisera for 6 anterior pituitary hormones. Reticulin...

Introduction: Gastrinomas are rare neuroendocrine tumours (NETs) that arise from enterochromaffin-like cells and produce gastrin. Most are discovered in the duodenum and pancreas. The clear cell type of renal cell carcinoma (RCC) is known for the expression of gastrin-releasing peptide receptor (GRP-R) and some studies have shown GRP can stimulate tumor cell proliferation and neoangiogenesis. Therefore, we present a case with metachronous development of renal cell carcinoma an...

IntroductionThe COVID-19 pandemic has significantly affected health systems all over the world, putting on a hold medical care and delaying surgical interventions. Patients with pituitary tumors, especially those who associate hormonal hypersecretion or defficiency and mass effects represent a management challenge even in a non-pandemic time.Case descriptionA 41 years old, non-smoker, overweight, male patient...

BackgroundIt has been well recognized that grade heterogenity exists within well-differentiated neuroendocrine tumors (WD-NETs). Targeted therapy plays an important role in metastatic disease control.Case presentationWe present the case of a 58-year-old male patient who was diagnosed with a pulmonary tumor on computer tomography (CT) and underwent a posterobasal left lobectomy. On immunohistochemical staining...

Introduction: Besides medullary thyroid carcinoma (MTC), increased calcitonin serum concentrations may be due, rarely, to neuroendocrine tumour (NET) ectopic secretion, especially those of the foregut (pancreatic/lung). Patients with NETs and right-sided heart failure due to cardiac carcinoid have a worse prognosis than those presenting without. Case presentation: We present the case of a 72-year-old female with a history of an initially considered well-...

Introduction: There is evidence on the association of subacute thyroiditis (SAT) and SARS-CoV-2 infection, the first case report being described in a young woman back in July 2020 (1). Multisystemic inflammatory syndrome in adults (MIS-A) is a rare complication of SARS-CoV-2, usually 2 to 12 weeks after initial infection. The development of Graves disease after SAT is rare, with approximately 31 reported cases, of which only 5 occurring in men (2). We pre...

Introduction: Neuroendocrine tumors (NETs) are rare tumors that originate in cells from the neural crest, widely distributed in the body. Genitourinary (GU) NETs occurring in the bladder represent less than 1% of these primary malignancies. We present the case of a patient with two metachronous bladder tumors, of which one is NET.Case report: Male patient, 52–year-old, ex–smoker, known with hypertension, dyslipidemia and benign prostatic hype...

Introduction: Folliculo-stellate cells (FSCs), non-endocrine star-like shaped population of cells located in the anterior pituitary, have very heterogenous function and phenotype. Located between the secretory cells, their first atributed role was connected to a supporting network. In literature, they were mentioned to be involved in the pathogenesis and evolution of pituitary neuroendocrine tumors (PitNETs).Objectives: Analyse FSCs characteristics and d...

Introduction: Somatotroph pituitary adenomas (PAs) represent 10-15% of all resected PAs, exhibiting immunohistochemical (IHC) positivity for GH (growth hormone) and PIT-1 transcription factor (TF). The histopathological (HP) and IHC variability of each PA influences the phenotype, radiological features, and therapy response.Materials and methods: The study included 33 patients with acromegaly, with men: women ratio of 17:16. The HP-IHC characteristics we...

Background: Multiple endocrine neoplasia type 1 (MEN1) is an inherited syndrome, characterized by primary MEN1 tumors: parathyroid, pancreatic and pituitary. We describe the case of a patient with MEN1 syndrome, initially presented with a gastric neuroendocrine tumor (NET).Case presentation: A 33-year-old male patient, initially treated for perforated gastric ulcer, presented 7 years later with dyspepsia, diarrhea and weight loss. Abdominal CT scan revea...